NMDA receptors cloned at last

Triheteromeric NMDA receptors at hippocampal synapses.

NMDA receptors are composed of two GluN1 (N1) and two GluN2 (N2) subunits. Constituent N2 subunits control the pharmacological and kinetic characteristics of the receptor. NMDA receptors in hippocampal or cortical neurons are often thought of as diheteromeric, meaning that they contain only one type of N2 subunit. However, triheteromeric receptors with more than one type of N2 subunit also have...

Mobile NMDA Receptors at Hippocampal Synapses

Glutamate receptors are concentrated in the postsynaptic complex of central synapses. This implies a highly organized and stable postsynaptic membrane with tightly anchored receptors. Recent reports of rapid AMPA receptor insertion and removal at synapses have challenged this view. We examined the stability of synaptic NMDA receptors on cultured hippocampal neurons using the open-channel blocke...

Algal Rhodopsins: Phototaxis Receptors Found at Last

The discovery of two distinct Chlamydomonas sensory receptors responsible for phototaxis reveals additional diversity among the microbial rhodopsins. Sequence and architecture comparisons among this growing family highlight key components for light-responsive functions.

Tweaking agonist efficacy at NMDA receptors by site-directed mutagenesis

Glutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration.

During cortical development, embryonic neurons migrate from germinal zones near the ventricle into the cortical plate, where they organize into layers. Mechanisms that direct neuronal migration may include molecules that act as chemoattractants. In rats, GABA, which localizes near the target destination for migrating cortical neurons, stimulates embryonic neuronal migration in vitro. In mice, g...